Kajian in silico Penghambatan Spesifik 3C-like Protease SARS-CoV-2 Senyawa Quinic Acid, Gluconic Acid, dan Ferulic Acid pada Kulit Kopi
نویسندگان
چکیده
Penelitian ini bertujuan mengeksplorasi senyawa kimia kulit kopi sebagai anti Covid-19 (anti-3C-like protease). Analisis in silico dilakukan dengan tahapan pengambilan struktur dan protein, preparasi penginteraksian protein 3CL-Pro. Docking program Molegro virtual Docker 5 divisualisasi Discovery Studio versi 21.1.1. Senyawa yang terkandung dalam kopi, yaitu quinic acid, gluconic acid maupun ferulic secara terpisah mengikat residu asam amino 3CL Protease sama satu lain. Selain itu, ketiga menghambat aktivitas sisi katalitik 3CLPro CYS145. Hal menunjukkan bahwa memiliki potensi materi terapi virus corona molekuler kinerja Protease, utamanya replikasi SARS-CoV-2.
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ژورنال
عنوان ژورنال: Jurnal Ilmiah Medicamento
سال: 2022
ISSN: ['2356-4814']
DOI: https://doi.org/10.36733/medicamento.v8i2.3971